Conclusions

Many experimentally induced rodent tumors express TSTAs which can induce an immune response that is capable of destroying neoplastic cells in vivo. Today there are also ways to induce a tumoricidal immune response against some tumors that are non-immunogenic when studied by the classical assays for TSTAs. T Lymphocytes play a key role in mediating the immunological destruction of most antigenic tumors. Antibody-mediated and cell-mediated immune reactions to human tumors have been identified and their targets characterized towards development of clinically beneficial immunotherapy.

See also: Antibodies, bispecific; Antibody-dependent cellular cytotoxicity; Cytokines; Cytotoxic T lymphocytes; Embryonic antigens; Epstein-Barr virus, infection and immunity; Helper T lymphocytes; Immunotherapy of tumors; Interleukin 2; Lymphokine-activated killer (LAK) cells; Natural killer (NK) cells; Papillomavirus, infection and immunity; Polyoma-virus, infection and immunity; Stress proteins; Targeting of immunological agents; Tumor antigens; Tumor necrosis factor a; Tumors, immunological escape of.

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