Conclusions

The I-J locus and gene product remain matters of great controversy at this time. Much of the skepticism concerning I-J will be alleviated once the I-J gene(s) has been cloned. More recent studies have suggested that the I-J determinant is associated with a 13 kDa protein termed the glvcosvlation-inhibiting factor. The glycosylation-inhibiting factor isolated from suppressor cells is recognized by I-J-specific antibodies and possesses suppressive activity. Additional questions remain, however, regarding the basis for the genetic restriction in the function of this factor, and the apparent haplotype-specificitv in the recognition by I-J-specific antibodies.

See also: H2 class II; MHC restriction; Suppressor T lymphocytes.

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