CSF1 and the CSF1 R in neoplasia

Viral oncogenic forms of fms cause feline fibrosarcomas. The 5' end of the CSF-1R is used approximately 20% of the time as an integration site for Friend murine leukemia virus-induced mouse myeloid leukemias. Autocrine regulation by CSF-1 is a characteristic of all irradiation-induced leukemias in SJL/J mice and of some myc retrovirus-induced mouse tumors. Circulating levels of CSF-l are elevated in patients with myeloid and lymphoid malignancies and carcinomas of the ovary, endometrium and breast. In ovarian cancer, elevated levels of CSF-1 in the circulation or ascitic fluid predict a poor prognosis. At least in some cases, the malignant cells themselves coexpress CSF-1 and the CSF-1 R, raising the possibility of autocrine/paracrine growth control by CSF-1 in selected human neoplasias.

See also: Bone marrow and hematopoiesis; Colony stimulating factors; Cytokine genes, regulation of; Cytokines; Granulocyte-macrophage colony stimulating factor (GM-CSF); Macrophage activation; Monocytes; Mononuclear phagocyte system.

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