Cytomorphologic infrastructure of exocytosis

Eukaryotic cells feature various membrane-delimited sacs embedded in a structured cytoplasmic matrix. These form a coherent set interconnected morphologically or via vesicular transport, thereby establishing a functionally continuous vectorial cisternal space (Figure 1), embedded within but topologicals distinct from the cytoplasm, 'outside' the cell much as our digestive tract is topologicals 'outside' our body. The cisternal space includes 1) the nuclear envelope, a perforated double-membraned sac continuous with 2) the endoplasmic reticulum, partly studded with ribosomes proximally (rough F.R, RER), but not so distally (smooth ER, SER), 3) the Golgi apparatus, a set of flattened sacs shaped like soup plates nested within each other that, among other functions, encapsulates cell products into 4) membranous intracellular transport vesicles. Free cytosolic polyribosomes synthesize constitutional proteins (cytoskeletal elements, cytoplasmic enzymes, dedicated proteins such as hemoglobin). Proteins destined 'for export', i.e. m- and s-exocytosis, are synthesized by polyribosomes attached to the RER and are either anchored within the RER membrane or extruded in toto into the cisternal space, whence they are translocated through the Golgi apparatus for post-translational modification and/or packaging, then sorted in the trans-Golgi network into either exocytotic vesicles or lyso-somes. Exocytotic vesicles with or without cargos of

Piss ma lemma s-Exocytosis

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