Deoxyguanosine metabolism and T lymphocyte ontogeny

An understanding of the toxicity of dGuo in T cells may be derived from knowledge of the distribution of the enzymes important in nucleoside metabolism in different lymphocyte subpopulations and at different stages of maturation. The critical enzymes are adenosine deaminase, PNP and deoxycytidine kinase (Figure 1). The more immature the T cell, the higher the levels of adenosine deaminase and deoxycytidine kinase and the lower the levels of PNP. Thus immature T cells are at risk for accumulating deoxyGTP.

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