Distinction between classical and alternative pathways

In experimental work, the two pathways of activation can be readily distinguished, in that both pathways require Mg2+, but only the classical pathway requires Ca2+ ions: if these are chelated by EGTA (ethyleneglycol-bis-(|3-amino-ethylether) tetra-acetic acid) and Mg2+ ions are added in excess, only the alternative pathway will function. Further, the activation of the alternative pathway is prevented by dilution of human serum beyond about ten-fold, and is generally considerably impaired after 2-3 days storage of human serum at 4°C: the classical pathway, via Clq, operates at lower concentrations of serum and is stabler on storage. The stability of activation occurring via MBL has not been extensively examined.

How To Bolster Your Immune System

How To Bolster Your Immune System

All Natural Immune Boosters Proven To Fight Infection, Disease And More. Discover A Natural, Safe Effective Way To Boost Your Immune System Using Ingredients From Your Kitchen Cupboard. The only common sense, no holds barred guide to hit the market today no gimmicks, no pills, just old fashioned common sense remedies to cure colds, influenza, viral infections and more.

Get My Free Audio Book

Post a comment