DIT nn

65 Vftrisble gene segments in 30 subfamilies ^_

29 Variable gene segments In 25 subfamilies M_

_annnrnnnainnifinnrrni

Mouse 5

Mouse a

Human p

Mouse |B

300 kb

1000kb

-lOOOkb

650 kb

700kb

Figure 1 Genomic organization of the human and mouse TCR loci. Arrows indicate gene segments whose transcriptional orientation is inverted with respect to the other gene segments in the locus, kb, kllobases.

Span of up to several hundred kilobytes

Span of scvcol kilobates

Rcavlalwy

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