Drugindependent autoimmune hemolytic anemias

In these cases the antibody reacts with the red cell in the absence of the drug. The anti-red cell autoantibodies seem to be serologically identical to those of 'idiopathic' warm-type autoimmune hemolytic anemia. The great majority of cases have followed the use of the anti-hypertension drug a-methyldopa (Aldomet). The red cells are coated with IgG and the serum contains autoantibodies which characteristically have Rh specificity.

In patients receiving a-methyldopa the autoantibody is often present (15-20%), but hemolysis is not common (<1 %). Studies of reticuloendothelial clearance in patients receiving a-methyldopa suggest that the drug itself may blockade the reticuloendothelial system in most patients, effectively blocking cell destruction by the autoantibody.

Other drugs that have been reported to act in a similar fashion to a-methyldopa include chlor-diazepoxide (Librium), mefenamic acid (Ponstan), flufenamic acid and indomethacin.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

Get My Free Ebook


Post a comment