Effects of IL13 on B lymphocytes

IL-13 induces IgG4 and IgE synthesis by human B cells cultured in the presence of activated CD4' T cells, anti-CD40 monoclonal antibodies (mAbs) or CD40 ligand (L) transfectants. In contrast to human B cells, IL-13 does not induce IgE by mouse B cells under conditions that induce IgE switching in response to IL-4, suggesting that mouse B cells lack functional IL-13R complexes. However, IL-4-deficient mice produce low levels of IgE in vivo, following viral or parasite infections, indicating that IL-4-independent IgE synthesis occurs in these mice. However, it is not known whether this IgEl production is mediated by IL-13.

The effects of IL-13 on human B cells are largely similar to those of IL-4, but IL-13 is generally less potent than IL-4 in inducing IgE synthesis.

IL-13 modulates the phenotype of normal human B cells. It upregulates the expression of CD23, CD71, CD72, surface IgM (slgM) and major histocompatibility complex (MHC) class II molecules on purified human B cells. IL-13 has growth-promoting activity on normal B cells stimulated by anti-IgM or anti-CD40 mAbs, but it inhibits IL-2-induced proliferation of chronic lymphocytic leukemia B cells, suggesting that IL-13 has antiproliferative effects on malignant B cells.

IL-13 does not have additive or synergistic effects with IL-4 when both cytokines are added at optimal concentrations, which is consistent with the observation that the receptors for IL-4 and IL-13 share a common component, which is important for signal transduction.

How To Bolster Your Immune System

How To Bolster Your Immune System

All Natural Immune Boosters Proven To Fight Infection, Disease And More. Discover A Natural, Safe Effective Way To Boost Your Immune System Using Ingredients From Your Kitchen Cupboard. The only common sense, no holds barred guide to hit the market today no gimmicks, no pills, just old fashioned common sense remedies to cure colds, influenza, viral infections and more.

Get My Free Audio Book


Post a comment