Endogenous IFNp induction

Circumstantial evidence points to a low level of IFNp production under various conditions in cell culture and in vivo in the absence of known IFN inducers, a situation which has been described as physiological, spontaneous or autocrine IFN|3 production. This endogenous IFN(3 has been implicated in control of cell growth and differentiation. Primary mouse macrophages proliferate in response to macrophage colony-stimulating factor (M-CSF). Inclusion of an antimouse IFNa/p serum further stimulates the mitogenic response and increases the susceptibility of the culture to virus infection. In mouse myeloid Ml cells, IFN|3 mRNA has been detected following differentiation by cytokines (e.g. M-CSF, TNFa, interleukin 6 (IL-6)) and differentiation was inhibited by antilFNp serum. Activities similar to those of IFNfJ have also been demonstrated in dimethyl sulfoxide (DMSO(-differentiated Friend erythroleukemia cells and in phorbol-12-mvr-istatc-13-acetate (PMA) differentiated U937 cells.

Endogenous IFN3 production is not restricted to cells of hematopoietic origin; IFN(3 RNA has been found in IE-1- and TNF-treated Hep-2 cells and is of crucial importance to the antiviral activity of TNF, whereas in FS-4 fibroblasts the mitogenic stimulus provided by TNF is enhanced by antibodies against IFN (3.

How To Bolster Your Immune System

How To Bolster Your Immune System

All Natural Immune Boosters Proven To Fight Infection, Disease And More. Discover A Natural, Safe Effective Way To Boost Your Immune System Using Ingredients From Your Kitchen Cupboard. The only common sense, no holds barred guide to hit the market today no gimmicks, no pills, just old fashioned common sense remedies to cure colds, influenza, viral infections and more.

Get My Free Audio Book

Post a comment