Evaluation of immunologic responsiveness

From the discussion of the canine immune system, it is clear that many similarities to the murine and human immune system are found. However, it is vital to realize that critical differences between these systems exist. It is tempting to directly apply a human or murine function test to assess the canine immune system. This direct application could yield erroneous results or interpretations. Often, all that is required is a minor alteration of the assay or its interpretation to make the assay applicable to the canine immune system. Since it is beyond the scope of this entry to discuss each assay and their potential alterations, the reader is referred to the Further reading section for more information.

See also: Autoimmune disease, spontaneous experimental models; Innate immunity; Maternal antibodies; Ontogeny of the immune response.

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