Evasive strategies by rabies virus

Rabies virus infection is characterized by a silent progression of the virus in the nervous system during the incubation period without any detectable humoral immune response. Moreover, infection can lead to asymptomatic carriers which excrete the virus, and the saliva from clinically normal animals may be infective for a few days before clinical disease. It is also noteworthy that viremia does not normally occur before the onset of clinical symptoms. Rabies virus has also been demonstrated in the brown fat of experimentally or naturally infected bats. Bats maintained in simulated hibernation retain a viable virus (multiplying at a very low rate or not at all) for weeks or months, and when returned to a warm environment, multiplication is initiated or increased.

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