Evasive strategies by the organism

Following primary infections in childhood, BKV and JCV are not cleared from the body but remain latent in the kidney and in B lymphocytes for an indefinite period of time. Virus reactivation may occur in as many as 50% of the previously infected seropositive adults in the face of severe immunosuppression. It is likely that CMI prevents or limits virus reactivation in healthy individuals. Impaired CMI, as may occur in physiological states such as pregnancy and aging, or in more severe conditions such as organ transplantation, immunosuppressive therapy and AIDS, results in virus reactivation and viruria.

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