Evasive strategies by the organism

HHV-6 infects cells of the immune system. A number of effects of such infection on cellular function have been described, although the in vivo significance of these phenomena are not clear. Virus-induced suppression of growth factor-induced maturation of marrow precursor cells and colony formation by marrow precursors may be important in inhibition of bone marrow engraftment following transplantation. Infection of peripheral blood lymphocyte cultures leads to interferon a, tumor necrosis factor a, and interleukin-ip production, and suppression of T cell function as evidenced by reduced interleukin 2 synthesis and cellular proliferation. Infection of CD8^ T cells leads to expression of surface CD4, and resultant susceptibility to infection with HIV.

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