Expression and nomenclature LFA1

LFA-1 is expressed on all leukocytes including B and T lymphocytes, monocytes, macrophages, neutrophils, basophils, and eosinophils, but is absent from nonhematopoietic tissues and human platelets. The a chain of LFA-1 is designated CDlla, and the |3 chain, CD 18. However, since historically no other names have been used for LFA-1, both 'LFA-1' and 'CDlla/CD18' are unambiguous.

Leukocyte integrins

The leukocyte integrins are heterodimeric molecules, found on leukocytes, all sharing a common 3 chain, CD18. In addition to CDlla (LFA-1), they include CDllb (also called complement receptor type 3 or Mac-1, prominent on phagocytes and eosinophils), CDllc and CD lid. The leukocyte integrin a chain genes are linked on human chromosome 16; the gene for CD18 is on human chromosome 21. There are several other families of integrins, each of which shares a different common (3 chain. All integrins are adhesion molecules, and all display temperature and divalent cation dependence for function. Although some nonleukocyte integrins require a highly eon-served Arg-Gly-Asp (RGD) in their ligands ic.g. fibronectin), none of the ICAMs which bind to LFA-1 contain the RGD sequence.

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