Expression and nomenclature LFA1

LFA-1 is expressed on all leukocytes including B and T lymphocytes, monocytes, macrophages, neutrophils, basophils, and eosinophils, but is absent from nonhematopoietic tissues and human platelets. The a chain of LFA-1 is designated CDlla, and the |3 chain, CD 18. However, since historically no other names have been used for LFA-1, both 'LFA-1' and 'CDlla/CD18' are unambiguous.

Leukocyte integrins

The leukocyte integrins are heterodimeric molecules, found on leukocytes, all sharing a common 3 chain, CD18. In addition to CDlla (LFA-1), they include CDllb (also called complement receptor type 3 or Mac-1, prominent on phagocytes and eosinophils), CDllc and CD lid. The leukocyte integrin a chain genes are linked on human chromosome 16; the gene for CD18 is on human chromosome 21. There are several other families of integrins, each of which shares a different common (3 chain. All integrins are adhesion molecules, and all display temperature and divalent cation dependence for function. Although some nonleukocyte integrins require a highly eon-served Arg-Gly-Asp (RGD) in their ligands ic.g. fibronectin), none of the ICAMs which bind to LFA-1 contain the RGD sequence.

How To Bolster Your Immune System

How To Bolster Your Immune System

All Natural Immune Boosters Proven To Fight Infection, Disease And More. Discover A Natural, Safe Effective Way To Boost Your Immune System Using Ingredients From Your Kitchen Cupboard. The only common sense, no holds barred guide to hit the market today no gimmicks, no pills, just old fashioned common sense remedies to cure colds, influenza, viral infections and more.

Get My Free Audio Book

Post a comment