Extrathymic sites of T cell production

Since the number of mature T cells in the secondary lymphoid organs remains high throughout life, it is often argued that maintenance of the T cell pool after the stage of thymic atrophy reflects de novo production of T cells in other organs, e.g. the gut, liver and bone marrow. Although some degree of T cell differentiation can occur in these organs, there is currently no clear evidence that such differentiation contributes to the formation of the typical a(3 T cells found in the blood, spleen and lymph nodes. The most likely explanation for the maintenance of the T cell pool size into old age is that T cells are intrinsically long lived. The thymus is vital for the initial formation of the T cell pool, but once the pool reaches its maximal size in young adult life generation of new T cells by the thymus becomes relatively unimportant. By puberty the thymus is largely redundant and atrophy ensues.

See also: Apoptosis; Thymic epithelium: potential role in regulatory T cell tolerance; T cell receptor, aP; Thymic hormones and peptides; T lymphocyte differentiation.

How To Bolster Your Immune System

How To Bolster Your Immune System

All Natural Immune Boosters Proven To Fight Infection, Disease And More. Discover A Natural, Safe Effective Way To Boost Your Immune System Using Ingredients From Your Kitchen Cupboard. The only common sense, no holds barred guide to hit the market today no gimmicks, no pills, just old fashioned common sense remedies to cure colds, influenza, viral infections and more.

Get My Free Audio Book


Post a comment