Fibronectin

Hemostasis

Wound healing

Immune response " Inflammation

Figure 1 Fibronectin is involved in many biological processes.

proteins (Figure 2). Interaction of FN with integrins is mainly mediated by the Arg-Gly-Asp (RGD) sequence that is incorporated in a stable protein scaffold provided by the tenth type III module. Additional residues (Pro-His-Ser-Arg-Asn) in the ninth type III module, known as the synergy region, are also involved in this interaction. In the same ninth type III module a binding site for allb03-inte-grin is also present. Another major cell-adhesive domain is termed IIICS (type III connecting segment). This domain contains three important integrin-bind-ing sites: Glu-Ile-Leu-Asp-Val-Pro-Ser (EILDVPS) in the CS1 region, Arg-Ala-Pro-Ser (REDV) in the CS5 region, and Ile-Asp-Ala-Pro-Ser (IDAPS) in the adjacent heparin-binding domain (Figure 2).

FN matrices are deposited in a temporally and spatially defined pattern and comprise both newly synthesized cellular and soluble FNs. All five type 1 modules present in the N-terminal are required for FN assembly into the fibrillar matrix. The ninth type I domain in the collagen-binding region, and the first type III domain also appear to form a functional unit that is involved in FN assembly. This process is mediated by integrins including o^Pi and av03.

FN is encoded by a single gene whose pre-mRNA can be alternatively spliced in three different regions. Different isoforms of FN result from alternative splicing of EDA and EDB modules and mostly of a region termed V (variable) or IIICS. Multiple alternative splicing occurs in this region and generates 20 potentially different forms of FN.

Synefqy

Heparin

Mahl* jiivenrtii^

EDB EDA IDAP5

Mahl* jiivenrtii^

Heparin

EDB EDA IDAP5

Synefqy

How To Bolster Your Immune System

How To Bolster Your Immune System

All Natural Immune Boosters Proven To Fight Infection, Disease And More. Discover A Natural, Safe Effective Way To Boost Your Immune System Using Ingredients From Your Kitchen Cupboard. The only common sense, no holds barred guide to hit the market today no gimmicks, no pills, just old fashioned common sense remedies to cure colds, influenza, viral infections and more.

Get My Free Audio Book


Post a comment