Formation and correction of heteroduplex DNA

The 1975 model of meiotic recombination of Mesel-son and Radding may be used to illustrate mechanisms of heteroduplex DNA formation. As shown in Figure 1, the model postulates that the event is initiated by a nick in one nucleotide strand. The 3' end at the nick may then serve as a primer for DNA polymerase (shaded circle labeled 'pol'), which dis-

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