Further reading

Betz AG, Milstein C, Gonzalez-Fernandez A, Panncll R. Larson T and Neuberger MS (1994) Elements reg ulating somatic hypermutation of an immunoglobulin k gene: critical role for the intron enhancer/matrix attachment region. Cell 77: 239-248. Green NS, Rabinowitz JL, Zhu M and Scharff Ml) (1995) Immunoglobulin variable region hypermutation in hybrids derived from a pre-B and a myeloma line. Pro ceedings of the National Academy of Sciences of the USA 92: 6304-6308. Kallberg E, Jainandunsing S, Gray D and Leanderson T (1996) Somatic mutation of immunoglobulin V genes in vitro. Science 271: 1285. Kelsoe G (1998) Germinal centers and immune responses.

Annual Review of Immunology, 16. Neuberger MS and Milstein C (1995) Somatic hypermutation. Current Opinion in immunology 7: 248-254.

Peters A and Storb U (1996) Somatic hypermutation ot immunoglobulin genes is linked to transcription initiation. Immunity 4: 57-65. Ray SK, Putterman C and Diamond B (1996) Pathogenic antibodies are routinely generated during the response to foreign antigen: a paradigm for autoimmune disease. Proceedings of the National Academy of Sciences of the USA 93: 2019-2024. Reynaud C-A, Garcia C, Hein WR and Weill J-C (1995. Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process. Cell 80-115-12.5.

Wagner SD and Neuberger MS (1996) Somatic hypermutation of immunoglobulin genes. Annual Review of Immunology 14: 441-457. Yelamos J, Klix N, Goyenechea et a I (1995) Targeting ot non-Ig sequences in place of the V segment by somatu hypermutation. Nature 376: 225-229.

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