Further reading

Bank TA and Mucenski MI- (1994) Gene targeting of the immune system: the surprises continue. Current Opinion in Biotechnology 5: 604-610. Bradley A (1987) Production and analysis of chimeric mice. In: Robertson EJ (ed) Temlocurcinomas and Embryonic Stem Cells: A Practical Approach, pp 113-151. Oxford: IRL Press. Capecchi MR (1989) Altering the genome by homologous recombination. Science 244: 1288-1292. Evans MJ and Kaufmann MH (1981) Establishment in culture of pluripotential cells from mouse embryos. Nature 292: 154-156. Gu H, Marth JD, Orban PC, Mossmann H and Rajewski K (1994) Deletion of the DNA polymerase P gene in T cells using tissue-specific gene targeting. Science 265: 103-106.

Mansour SL, Thomas KR and Capecchi MR (1988) Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature 336: 348-352.

Martin GR (1981) Isolation of a pluriopotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells, l'7-oceedings of the National Academy of Sciences of the USA 78: 7634-7638.

Mintz B and Illmensee K (1975) Normal genetically mosaic mice produced from malignant teratocarcinoma cells. Proceedings of the National Academy of Sciences of the USA 72: 3585-3589. Orban PC, Chui D and Marth JD (1992) Tisue- and site-specific DNA recombination in transgenic mice. Proceedings of the National Academy of Sciences of the USA 89: 6861-6865. Parham P (ed) (1998) Transgenic and knockout models of human disease. Immunological Reviews 167. Rajewsky K, Gu H, Kiihn R et al (1996) Conditional gene targeting .Journal of Clinical Investigation 98: S51-53. Rohlmann A, Gotthardt M, Willnow TE, Hammer RK and Herz J (1996) Sustained somatic gene inactivation by-viral transfer of Cre recombinase. Nature Biotechnology 14: 1562-1565. Sauer B and Henderson N (1988) Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage PI. Proceedings of the National Academy of Sciences of the USA 85: 5166-5170.

Smithies O (1993) Animal models of human genetic diseases. Trends in Genetics 9: 112-116. Willnow TE and Herz J (1994) Homologous recombination for gene replacement in mouse cell lines. Methods in Cell Biology 43: 305-334.

Yeung RSM, Penningcr J and Mak 'I'W (1994) T-cell development and function in gene-knockout mice. Current Opinion in Immunology 6: 298-307.

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