Further reading

Green JM, Noel PJ, Sperling Al et al (1994) Absence of B7-dependent responses in CD28 deficient mice. Immunity 1: 501-508. June CH, Bluestone JA, Nadler LM and Thompson CB (1994) The B7 and CD28 receptor families. Immunology Today 15: 321-332. Krummel MF and Allison JP (1995) CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. Journal of Experimental Medicine 182, 459^165.

Lenschow DJ, Walunas TL and Bluestone JA (1996) CD28/B7 system of T cell costimulation. Annual Review of Immunology 14: 233-258. Linsley PS and Ledbetter JA (1993) The role of the CD28

receptor during T cell responses to antigen. Annual Review of Immunology 11: 191-211.

Linsley PS, Brady W, Urnes M, Grosmaire LS, Damle NK and Ledbetter J A (1991) CTLA-4 is a second receptor for the B cell activation antigen B7. Journal of Experimental Medicine 174: 561-569.

Lucas PJ, Negishi I, Nakayama K, Fields LE and Loh DH (1995) Naive CD28-deficient T cells can initiate but not sustain an in vitro antigen-specific immune response. Journal of Immunology 154: 5757-5768.

Marengere LEM, Waterhouse P, Duncan GS, Mittrucker H-W, Feng G-S and Mak TW (1996) Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. Science 272: 1170-1173.

Shahinian A, Pfeffer K, Lee KP et al. (1993) Differential T cell costimulatory requirements in CD28-deficient mice. Science 261: 609-612.

Sperling AI and Bluestone JA (1996) The complexities of T-cell co-stimulation: CD28 and beyond. Immunological Reviews 153: 155-182.

Truitt KE, Nagel T, Suen LF and Imboden JB (1996) Structural requirements for CD28-mediated costimulation of IL-2 production in Jurkat T cells. Journal of Immunology 156; 4539-4541.

Walunus TL, Lenschow DJ, Bakker CY et al (1994) CTLA-4 can function as a negative regulator of T cell activation. Immunity Is 405—413.

Waterhouse P, Penninger JM, Timms E et al (1995) Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4. Science 270: 985-988.

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