Further reading

Adair J and Bright S (1995) Progress with humanised antibodies: an update. Expert Opinion Investigational Drugs 4: 863-870. Adair J and Harris WJ (eds) (1997) Antibody Therapeutics. Boca Raton: CRC Press. Borrebaeck CAK (ed) (1995) Antibody Engineering: A

Practical Guide. New York: Oxford University Press. Chothia C, Lesk AM, Gerardi E et al (1992) Structural repertoire of the human VH segments. Journal of Molecular Biology 227: 799-817.

Emery S and Adair JR (1994) Humanised monoclonal antibodies for therapeutic applications. Expert Opinion Investigational Drugs 3: 241-251.

Eshhar Z (ed) (1995) A Companion to Methods in Enzy-mology: Chemric Antibodies Production and Applications. 8: 71-157.

Gussow D and Seeman G (1991) Humanisation of monoclonal antibodies. Methods in Enzytnology 203: 99-121.

Harris WJ (1994) Humanizing monoclonal antibodies for in vivo use. In: Spiers RE and Griffiths JB (eds) Animal Cell Biotechnology, vol 6, pp 259-279. London: Academic Press.

Harris WJ and Cunningham CC (1995) Antibody Therapeutics, Austin TX: RG Landes.

Hogenboom H and Chiswell D (1996) Antibody Engineering: A Practical Approach. McCafferty J (ed) Oxford.

Jones PT, Dear PH, Eoote J et al (1986) Replacing the complementary determining regions in a human antibody with those from a mouse. Nature 321: 522-525.

Mountain A and Adair JR (1992) Engineering antibodies for therapy. Biotechnology and Genetic Engineering Reviews 10: 1-142.

Padlan EA (1991) A possible procedure for reducing the immunogenicity of antibody variable domains while preserving their ligand binding properties. Molecular Immunology 28: 489-498.

Winter G and Harris WJ (1993) Humanized antibodies. Immunology Today 14: 243-246.

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