Further reading

Celada F and Seiden PE (1996) Affinity maturation and hypermutation in a simulation of the humoral immune response. European Journal of Immunology 26: 1350-1358.

Day ED (1990) Advanced Immunocbemistry, pp 603-642.

New York: Wiley-Liss. Eisen HN and Siskind GW (1964) Variations in affinities of antibodies during the immune response. Biochemistry 3: 996-1008.

Jerne NK (1974) Toward a network theory of the immune system. Annals of Immunology (Paris) 125C: 373-389.

Karush F (1978) The affinity of antibody: Range, variability and the role of multivalence. Comprehensive Immunology 5: 85-116.

Male DK and Roitt IM (1998) Introduction to the immune system. In: Roitt IM, Brostoff J and Male DK (eds) Immunology, 5th edn, pp 1-12. London: Mosby.

Milstein C and Neuberger MS (1996) Maturation of the immune response. Advances in Protein Chemistry 49: 451-485.

Pulendran B, Smith KG and Nossal GJ (1995) Soluble antigen can impede affinity maturation and the germinal center reaction but enhance extrafollicular immunoglobulin production. Journal of Immunology 155: 1141-1150.

Reiner SL and Seder RA (1995) T helper cell differentiation in immune response. Current Opinion in Immunology 7: 360-366.

Vora KA and Manser T (1995) Altering the antibody repertoire via transgene homologous recombinations: evidence for global and clone-autonomous regulation of antigen-driven B cell differentiation. Journal of Experimental Medicine 181: 271-281.

Voss EW Jr (1990) Antibody and immunoglobulin: structure and function. In: Ram BP, Harris MC and Tyler P (eds) Immunology: Clinical, Fundamental, and Therapeutic Aspects, pp 49-88. New York: VCH.

Voss EW Jr, Moore JK, Weidner-McGufficke KM, Denzin LK, Bedzyk WD and Voss VH (1992) Autologous antimetatype immune response in rabbits. Molecular Immunology 29: 241-249.

Yuhasz SC, Parry C, Strand M and Amzel LM (1995) Structural analysis of affinity maturation: the three-dimensional structures of complexes of an anti-nitro-phenol antibody. Molecular Immunology 32: 1143-1155.

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