Further reading

Cella M, Scheidegger D, Palmer-Lehmann K, Lane P, I.an-zavecchia A and Alber G (1996) Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. Journal of Experimental Medicine 184: 747-752. Gately MK, Renzetti LM, Magram J et al (1998) Interleu-kin-12/interleukin-12 receptor system: role in normal and pathologic immune responses. Annual Review Immunology 16: 495-521. Germann T, Huhn H, Zimmerman F and Rüde E (1987) An antigen-independent physiological activation pathway for L3T4+ T lymphocytes. European Journal of Immunology 17: 775-781. Germann T and Rüde E (1995) Interleukin-12. International Archives of Allergy and Immunology 108: 103-112.

Gerosa F, Paganin C, Peritt D et al (1996) Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon--/ and interleukin-10. Journal of Experimental Medicine 183: 2559-2569. Hall SS (1995) IL-12 at the crossroads. Science 268: 1432-1434.

Hoffman SL, Crutcher JM, Puri SK et al (1997) Sterile protection of monkeys against malaria after administration of interleukin-12. Nature Medicine 3: 80-83. Hu-I.i J, Huang H, Ryan J and Paul WE (1997) In differentiated CD4 T cells, interleukin 4 production is cytokine-autonomous, whereas interferon gamma production is cytokine dependent. Proceedings of the National Academy of Sciences of the USA 94: 3189-3194.

Jeannin P, Delneste Y, Seveso M, Life P and Bonnefoy J-Y (1996) IL-12 synergizes with IL-2 and other stimuli in inducing IL-10 production by human T cells. Journal of Immunology 156: 3159-3165. Karp, CL, Wysocka M, Wahl LM et al (1996) Mechanism of suppression of cell-mediated immunity by measles virus. Science 273: 228-231. Kato T, Inoue T, Yamamoto K, Tamura T and Nariuchi H (1992) Induction of IL-2 receptor expression and proliferation of T cell clones by a novel cytokine(s). Cellular Immunology 142: 79-93. Klinman DM, Yi AK, Beaucage SL, Conover J and Krieg AM (1996) CpG motifs present in bacteria DNA

rapidly induce lymphocytes to secrctc interleukin 6, interleukin 12, and interferon gamma. Proceedings of the National Academy of Sciences of the USA 93: 2879-2883.

Kobayashi M, Fitz L, Ryan M et al (1989) identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biological effects on human lymphocytes. Journal of Experimental Medicine 170: 827-845.

Koch F, Stanzl U, jennewein P et al (1996) High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregui-ation by II.-4 and IL-10. Journal of Experimental Medicine 184: 741-746.

Lotze M, Trinchieri G, Gately M and Wolf S teds) (1996) Interleukin 12: cellular and molecular immunology of an important regulatory cytokine. Annals of the New York Academy of Science 795: 1-457.

Presky DH, Yang H, Minetti LJ et a! (1996) A functional interleukin 12 receptor complex is composed of two ¡3-type cytokine receptor subunits. Proceedings uf the National Academy of Sciences of the USA 93: 14002-14007.

Rogge L, Barberis-Maino L, Biffi M, Passini N, Presky DH, Gubler li and Sinigaglia F (1997) Selective expression of an interleukin-12 receptor component by human T helper 1 cells. Journal of Experimental Medicine 185: 825-831.

Szabo SJ, Dighe AS, Gubler U and Murphy KM (1997) Regulation of the interleukin (ll.)-12R|i2 subunit expression in developing T helper I (Th 1) and Th2 cells. Journal of Experimental Medicine 185: 817-824.

Tone Y, Thompson SA, Babik JM et al (1996) Structure and chromosomal location of the mouse interleukin-12 p35 and p40 subunit genes. European journal of Immunology 26: 1222-1227.

Trinchieri G (1995) Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immun ity. Annual Review of Immunology 13: 2.51-276.

Trinchieri G and Scott P (Organizers) (1995) 62nd Forum in Immunology: Immunorcgulation by interleukin-12. Research in Immunology 146: 423-65 I.

Wu Cy, Warrier RR, Wang X, Presky DH and Gatelv Mk (1997) Regulation of interleukin-12 receptor B, chain expression and interleukin-12 binding by human peri pheral blood mononuclear cells. European Journal of Immunology 27: 147-154.

Yoshimoto T, Kojima K, Funakoshi T, Endo V, Fuiita T and Nariuchi H (1996) Molecular cloning and charac terization of murine IL-12 genes, lournal of Immunology 156: 1082-1088.

Yoshimoto T, Okamura H, Tagawa Y-I, Iwakura Y and Nakanishi K (1997) Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-7 production from activated B cells. Proceedings of the National Academy of Sciences of the USA 94: 3948-3953.

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