Further reading

Alt FW, Oltz EM, Young F, Gorman J, Taccioli G and Chen J (1992) VDJ recombination. Immunology Today 13: 306-314.

Cook CP and Tomlinson IM (1995) The human immunoglobulin V,, repertoire. Immunology Today 16: 237-242.

Corbett SJ, Tomlinson IM, Sonnhammer ELL, Buck D and Winter G (1997) Sequence of the human immunoglobulin diversity (D) segment locus: A systematic analysis provides no evidence for the use of DIR segments, inverted D segments, "minor" D segments or D-D recombination. Journal of Molecular Biology 270: 587-597.

Flanagan JC and Rabbitts TH (1982) Arrangements of human immunoglobulin heavy-chain constant region genes implies evolutionary duplication of a segment containing 7, e and a genes. Nature 300: 709-713.

Hieter PA, Max EE, Seidman JG, Maizel JVJ and Leder P (1980) Cloned human and mouse kappa-immuno-globulin constant and J region genes conserve homology in functional segments. Cell 22: 197-207.

Hieter PA, Maizel JV and Leder P (1982) Evolution of human immunoglobulin k J region genes. Journal of Biological Chemistry 257: 1516-1522.

Honjo T and Alt FW (eds) (1995) Immunoglobulin Genes, 2nd edn. London: Academic Press.

Ichihara Y, Matsuoka H and Kurosawa Y ( 1988) Organisation of human immunoglobulin heavy chain diversity-gene loci. EMBO Journal 7: 4141-4150.

Ignatovich O, Tomlinson IM, Jones PT and Winter G (1997) The creation of diversity in the human immunoglobulin Vx repertoire, Journal of Molecular Biology 268: 69-77.

Kabat EA and Wu TT (1971) Attempts to locate complementarity-determining residues in the variable positions of light and heavy-chains. Annals of the New York Academy of Sciences 190: 382-393.

Max EE, Battey J, Ney R, Kirsch IR and Leder P (1982) Duplication and deletion in the human immunoglobulin e genes. Cell 29: 691-699.

Neuberger MS and Milstein C (1995) Somatic hypermutation. Current Opinion in Immunology 7: 248-254.

Parham P (ed) (1998) Somatic hypermutation of immunoglobulin genes. Immunological Reviews 162.

Ravetch JV, Siebenlist U, Korsmeyer S, Waldmann T and Leder P (1981) Structure of the human immunoglobulin p. locus: characterization of embryonic and rearranged J and D genes. Cell 27: 583-591.

Takahashi N, Ueda S, Obata M, Nikaido T, Nakai S and Honjo T (1982) Structure of human immunoglobulin gamma genes: implications for evolution of a gene family. Cell 29: 671-679.

Tomlinson IM, Walter G, Jones PT, Dear PH, Sonnhammer ELL and Winter G (1996) The imprint of somatic hypermutation on the repertoire of human germline V genes. Journal of Molecular Biology 256: 813-817.

Tonegawa S (1982) Somatic generation of antibody diversity. Nature 302: 575-581.

Vasicek TJ and Leder P (1990) Structure and expression of the human immunoglobulin \ genes. Journal of Experimental Medicine 172: 609-620.

Williams SC, Frippiat J-P, Tomlinson IM, Ignatovich O, Lefranc M-P and Winter G (1996) Sequence and evolution of the human germline VA repertoire. Journal of Molecular Biology 264: 220-232.

Zachau HG (1993) The immunoglobulin k locus - or -what has been learned from looking closely at one-tenth of a percent of the human genome. Gene 135: 167-!"7!.

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