Further reading

Aiken C, Konver J, Landau NR, Lcnburg MF. and Trono D (1994) Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane proximal CD4 cytoplasmic domain. Cell 76: 853-864.

Cammarota G, Scheirle A, Takacs B et al (1992) Identification of a CD4 binding site on the j32 domain of HLA-DR molecules. Nature 356: 799-801.

Eiden LE and Lifson JD (1992) HIV interaction with CD4: a continuum of conformation and consequences. Immunology Today 13: 201-201.

Fleury S, Thibodeau J, Croteau G et al (1995) HLA-DR polymorphism affects the interaction with CD4. Journal of Experimental Medicine 182: 733-741.

Fleury S, Huang B, Zerbib A, Croteau G, Long EO and Sekaly RP (1996) Mutations in human CD4 impair the functional interaction with different human and mouse class II isotypes and alleles. Journal of Immunology 156: 1848-1855.

Janeway CA (1992) The T cell receptor as a multicom-ponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation. Annual Review of Immunology 10: 487-512.

Julius M, Maroun CR and Haughn L (1993) Distinct roles for CD4 and CD8 as co-receptors in antigen receptor signaling. Immunology Today 14: 177-184.

Konig R, Fleury S and Germain RN (1996) The structural basis of CD4-MHC class II interactions: coreceptor contributions to T cell receptor antigen recognition and oligomerization-dependent signal transduction. Current Topics in Microbiology and Immunology 205: 19-46.

Pantaleo G and Fauci AS (1995) New concepts in the immunopathogenesis of HIV infection. Annual Review of Immunology 13: 487-512.

Parnes JR (1989) Biology and function of CD4 and CD8. Advances in Immunology 44: 265-311.

Rudd CE, Jannsson O, Cai YC, da Silva AJ, Raab M and Prasad KVS (1994) Two-step TCRf/CD3-CD4 and CD28 signaling in T cells: SH2/SH3 domains, protcin-tyrosine and lipid kinase. Immunology Today 15: 225-234.

Sawada S, Scarborough JD, Killeen N and Littman DR (1994) A lineage-specific transcriptional silencer regulates CD4 gene expression during T cell development. Cell 77: 917-929.

Sweet RW, Truneh A and Hendrickson WA (1991) CD4: its structure, role and immune function in AIDS pathogenesis, and potential pharmacological targets. Current Opinion in Biotechnology 2: 622-633.

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