Further reading

Anderson G, Moore NC, Owen JJT and jenkinson h[ (1996) Cellular interactions in thymocyte development. Annual Review of Immunology 14: 73-100. Berg LJ, Pullen AM, Fazekas de St. Groth B, Mathis D, Benoist C and Davis MM (1989) Antigcn/MHC specific T cells are preferentially exported from the thymus in the presence of rheir MHC ligand. Cell 58: 1035-104b. Borst J, Jacobs H and Brouns G (1996) Composition and function of T-cell receptor and B-cell receptor complexes on precursors lymphocytes. Current Opinion in Immunology 8: 181-190. Kappler JW, Roehm N and Marrack P (1987) 1 cell tolerance by clonal elimination in the thymus. Cell 49; 273-280.

Kisielow P, Bluthman H, Staerz UD, Steinmetz. M and von Boehmer H (1988) Tolerance in T cell receptor trans genie mice involves deletion of nonmature CD4 CD8 thymocytes. Nature 333: 742-746. Kruisbeek AM and Amsen D (1996) Mechanisms underlying T cell tolerance. Current Opinion in Immunology 8: 233-244.

Littman D (1998) Regulation of CD4 and CDS gene expression during thymocyte lineage commitment. Annual Review of Immunology, 16.

Malissen B and Malissen M (1996) Functions of TCR and pre-TCR subunits: lessons from gene ablation. Current Opinion in Immunology 8: 383-393.

Perlmutter RM and Alberola-Ila J (1996) The use of domi-nant-negative mutations to elucidate signal transduction pathways in lymphocytes. Current Opinion in Immunology 8: 285-290.

Scott, B, Bliithman, Teh HS and von Boehmcr H (1989) The generation of mature T cells requires interaction of the tx(3 T cell receptor with major histocompatibility antigens. Nature 338: 591-593.

Shortman K and Li W (1996) Early T lymphocyte progenitors. Annual Review of Immunology 14: 29-48.

Speiser DE, Lees RK, Hengartner H, Zinkernagel RM and MacDonald HR (1989) Positive and negative selection of T cell receptor Vß domains controlled by distinct cell populations in the thymus. Journal of Experimental Medicine 170: 2165-2170.

Züniga-Pflücker JC and Lenardo MJ (1996) Regulation of thymocyte development from immature progenitors. Current Opinion in Immunology 8: 215-224.

Züniga-Pflücker JC, Longo DL and Kruisbeek AM ¡1989: Positive selection of CD4 CD8 ' T cells in rhe thymus of normal mice. Nature 338: 76-78.

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