G

(Broad)

Belongs to the Ig and receptor tyrosine kinase 150 family (see CD117, CD135, CD140a, CD140b). The cytoplasmic region contains a protein tyrosine kinase domain Member of the cytokine receptor (hematopoietin) 75-85 superfamily. Upon association with CDw131 (common to CDw123 and CDw125), it forms the high-affinity GM-CSF receptor Belongs to the Ig and receptor tyrosine kinase 145 family (see CD115, CD135, CD140a, CD140b) Related to the interferon al¡3 receptor and the 90-100

CD142 molecule Member of the TNF/NGF receptor family (see 50-60 CD27, CD30, CD40, CD95, CD120b, CD134, CDw137). It binds both TNF« and /3 with high affinity

Member of the TNF/NGF receptor family (see 75-85 CD27, CD30, CD40, CD95, CD120a, CD134, CDw137). It binds both TNF« and /3 with high affinity

Binds both IL-1 a and IL-1 /3 with high affinity, as 80

well as the IL-1 receptor antagonist Binds both IL-1 a and IL-1 >3 with high affinity, as 60-70

well as the IL-1 receptor antagonist Member of the cytokine receptor (hematopoietin) 75 superfamily. Binds IL-2 with low affinity. Noncovaiently associates with the CD25 molecule and the CD132 molecule (common to CD124 and CD127 molecules) to the high-affinity IL-2 receptor complex. Also part of the IL-15 receptor complex Associates with CDw131 (common to CD116 and 70

CDw125) to form the functional IL-3 receptor Receptor subunit for IL-4 and IL-13 by 140

noncovaiently associating with the CD132 molecule or the IL-13 receptor, respectively Associates with CDw131 (common to CD116 and 60

CDw123) to form the functional IL-5 receptor Binds IL-6 with low affinity. Noncovaiently 80

associates with the CD130 molecule to form the functional high-affinity IL-6 receptor Associates with the CD132 molecule, which 75

results in augmentation of binding affinity and internalization of IL-7 The two identified forms are members of the 58-67 rhodopsin superfamily that contain seven transmembrane domains and couple to GTP-binding proteins Binds oncostatin M (OSM) with low affinity. 130

Noncovaiently associates with the CD126 molecule to form the high-affinity receptor for IL-6. Signal transducing component of the IL-11 receptor. Upon association with the leukemia inhibitory factor (LIF) receptor, the high-affinity receptor for LIF, OSM and cardiotrophin-1 is generated. This functional LIF/OSM receptor is probably converted to the ciliary neurotrophic factor (CNTF) receptor upon association with the CNTF binding protein

Table 1 Continued

Other name (s)

Main reactivity of mAbs

Short characteristic of the CD molecule

Molecular weight reduced (kDa)

CDw131 Common ß chain

CD 132 Common y chain

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