General background

Serum therapy using human immunoglobulins as intravenous immune globulin (IVIG) has been used successfully in a number of disease states. However, such polyclonal sera is expensive to collect, particularly high titer sera against specific diseases, and problems of contamination with viruses such as hepatitis B and human immunodeficiency virus limits the use of human materials.

In the last 15 years, over 50 different rodent monoclonals have been evaluated in studies of imaging (tumors, blood clots) and therapy (tumors, blood clots, immunosuppression). While the data show that these monoclonals can effectively target in vivo, they

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