Generation of mice from genetically modified embryonic stem cells

The capability to introduce genetic modifications such as gene disruptions into mice is based on initial studies by Mintz, extended by Evans and Kaufmann and Martin. Their studies demonstrated that embryonic stem cells (ES cells), derived from the inner cell mass of the early mouse embryos, could be propagated and manipulated in culture without losing their pluripotency. After reintroduction into blastocysts these cells colonized many tissues of the developing embryo including the germiine. This offered the

Wild-type alle!«

Targeting construct

Floxed alíete

Disrupted allele

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