Genome

HHV-8 genomes are present in KS spindle and endothelial cells, which are believed to represent the neoplastic component of this tumor. In KS tissue and in BCBL cells HHV-8 genomes are present as circular episomes and therefore probably persist in a latent form in these tissues. In situ hybridization studies using probes for latent HHV-8 genes have confirmed this conclusion. The HHV-8 genome contains several genes which could conceivably interfere with cell cycle control, cellular transcription or intracellular signaling: these include a bcl-2 homologue (orf 16), a cyclin D2-like protein (orf 72), an interleukin 6 (IL-6)-like protein (orf K2), chemokine homologs (orfs K4, K.6), an interferon regulatory protein (orf K9), and a G protein-coupled receptor homolog (orf 74). The cyclin homolog is capable of interacting with cdk 6 to phosphorylate the retinoblastoma protein RB, and is expressed in KS tissue and in BCBL cells, but whether it, or any of the other viral proteins, plays a role in cellular transformation is not yet known and there is as yet no in vivo or in vitro evidence that HHV-8 is indeed a transforming rhadinovirus.

How To Bolster Your Immune System

How To Bolster Your Immune System

All Natural Immune Boosters Proven To Fight Infection, Disease And More. Discover A Natural, Safe Effective Way To Boost Your Immune System Using Ingredients From Your Kitchen Cupboard. The only common sense, no holds barred guide to hit the market today no gimmicks, no pills, just old fashioned common sense remedies to cure colds, influenza, viral infections and more.

Get My Free Audio Book


Post a comment