H2 class III genes

The proto-oncogene lnt3 is located approximately 200 kb telomeric from H2-Ea. Int3 is a member of the mouse Notch receptor family which all transduce proliferative signals by directly interacting with the DNA-binding protein RBP-J kappa. The Int3 locus is a target for integration of mouse mammary tumor viruses, which are frequently associated with primary mouse mammary tumors. Such tumors contain a truncated transcript containing the whole intracellular part of the Int3 product. Analysis of transgenic mice containing the tumor-specific truncated forms of Int3 suggest that deregulation of the Int3 gene in the mammary epithelial cells limits their capacity to perform apoptotic decisions.

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