Host genes control infection

The overall rate of replication of infectivity, and hence the incubation period of the disease, depends primarily on the interaction between the strain(s) of pathogen and the genotype of the affected animal. The mouse has a single genetic locus. Sine, with two alleles s7 and p7, which is the major determinant of its survival time when challenged by a standard dose of scrapie. Depending on the Sine genotype, the incubation period can vary from a few months to beyond the lifespan of the mouse (>2 years). PrP is

Infection in periphery

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