Humanized products

Over 100 humanized antibodies have been described in the scientific and patent literature. They represent a broad range of target antigens including anti-infectives, anticancer, immunosuppressor and immunomodulators for treatment of autoimmune disease. The majority have been humanized as IgGl molecules. This has been out of choice to maximize the facility for complement-dependent killing and Fc-mediated cytotoxicity. In cases where blocking of target antigen alone is preferred and to reduce binding to Fc receptors on non-target cells, as with CD4 or tumor necrosis factor a (TNFa) targets, IgG4 or IgGl mutants defective in FcR binding have been produced.

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