Breakdown of microfilament network rv o o



C2I + C2II

The other three form an iota subgroup in that antibodies will cross-react within this group but not with C. botulinum C2 toxin. Only within the iota group are the binding components interchangeable. The iota group will also modify all mammalian actin isoforms.

Other examples of binary toxins are staphylococcal leukocidin and staphylococcal y-hemolysin.

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