Uju

Factor VI H

CfyoprecpSate-pJJor plasma ¡läelör IK cörrpfcx)

Fraction I (fibrinogen)

Fraction I supernatant

FmeNan II + II supernatant (albumin)

Frftthari II - Iii w pjeerpitale

Fraction II ■+ III w sjpemalanl

Fraction )H precipitate

Ftaclian HI superrolsnl fraction II puce jpiiAie

(y-globulins)

Fraction 11 UfHimlart

Figure 2 Cohn-Oncley alcohol fractionation. Plasma fractionation procedures yield a gammaglobulin concentrate (fraction II).

undertaken between 1948 and 1955 following the discovery that myeloma proteins were immunoglobulin molecules. IgG and IgM were described first, followed by IgA (1960), IgD (1965) and IgE (1966). In 1964, following the discovery that animal IgG protein could be subdivided, it was found that human IgG was composed of four classes: IgGl, IgG2, IgG3 and IgG4.

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