Immune reactivity against vector proteins and transgene products

Gene therapy will probably require multiple injection of vectors or of genetically modified cells, which emphasizes the possibility of immune-mediated inac-tivation of the treatment. Retroviral, AAV and plas-mid vectors seem to be insufficiently antigen to induce an immune reaction by themselves. It is worth noting that major concerns have been raised about immune reaction against viral proteins encoded by the remaining genome of adenoviral vectors, and work is now in progress to construct vectors devoid of viral sequences (gutless vectors) or which are less immunogenic. Immune reactions against heterologous transgene products, which can synergize with immune reactivity directed against viral vector protein, have already been described for all types of vectors.

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