Immunoglobulin Ig superfamily

Cell surface proteins of the Ig superfamily are characterized by the presence of a variable number of related 70-110 amino acid Ig-like domains originally described in the Ig variable and constant regions. Several IgSF members have been implicated in cell adhesion. CD2 has been shown to bind several distinct ligands, including the IgSF members CD58, CD48 and CD59. CD31, which can mediate homo-philic adhesion, has also been implicated in binding to the avprintegrin. The integrin counter-receptors ICAM-1, ICAM-2, ICAM-3, VCAM-1 and MAdCAM-1 (Table 1) round out the list of IgSF adhesion molecules described to date. MAdCAM-1 is a unique IgSF member in that it contains mucin-like properties in addition to Ig domains (see below).

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