In vivo responses to HY

The fact that females of some but not all strains of mice rejected syngeneic male grafts suggested that there were genetic factors controlling the ability to mount an in vivo immune response to H-Y. These were explored in the early 1970s by Bailey, who found that genes of the MHC were the most important of the immune response (Ir) genes and, in particular, mice of the H-21' haplotype, regardless of other genetic differences, were able to reject syngeneic male grafts, whereas very few non-H-2b could do so. The H-2 genes controlling H-Y graft rejection were mapped toward the K end of the H-2 region by Bailey and subsequently, in 1978, into the class II region by Hurme and colleagues. The nature of non-responsiveness was explored from a different angle by Silvers in the early 1970s. He established that failure to respond was not due to the absence of the antigen in non-responder strains, that responsiveness was dominant in F1 hybrids between a responder and non-responder strains, and he found no evidence for allelism in H-Y. These findings have subsequently been confirmed and extended by others, including those investigating in vitro T cell responses to H-Y.

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