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"Genetically based numerical terminology devised by the International Society of Blood Transfusion.

"Examples for receptor functions of blood group antigens are: Le(b), Helicobacter pylori, Fy6, Plasmodium vivax, interleukin 8: P. parvovirus B19 (ISBT 209 GLOBO collection of antigens); AnWj, Haemophilus influenzae (ISBT 901 series of high incidence antigens). With the exception of Lewis antigens, all antigens are present on fetal red cells, albeit some antigens may be expressed with a reduced number of antigens per cell.

"Genetically based numerical terminology devised by the International Society of Blood Transfusion.

"Examples for receptor functions of blood group antigens are: Le(b), Helicobacter pylori, Fy6, Plasmodium vivax, interleukin 8: P. parvovirus B19 (ISBT 209 GLOBO collection of antigens); AnWj, Haemophilus influenzae (ISBT 901 series of high incidence antigens). With the exception of Lewis antigens, all antigens are present on fetal red cells, albeit some antigens may be expressed with a reduced number of antigens per cell.

Table 4 Parameters relevant for the immunological consequences of blood transfusion

Blood component preparation technique Content of therapeutically Intended cellular and plasmatic components

Erythrocytes, thrombocytes, granulocytes and plasma Contamination by constituents not intended for therapy White blood cells (WBC) (in all blood components) Plasma (in all cellular components) Erythrocytes (in platelet and plasma components) Number and viability of donor WBC Preparation technique Storage conditions (time, temperature) Gamma or ultraviolet irradiation Content of stem cells and T cells Ratio of T cells/stem cells Immunocompetence of recipient Age of patient (fetus, newborn, elderly) Underlying disease (lymphoma, immunodeficiency diseases) Concurrent therapies (chemotherapy, bone marrow depletion, immunosuppressive therapies) HLA-relatlonship between donor and recipient Accidental similarity dependent on ethnic backgrounds Intended similarity in organ transplants contaminated by WBC and HI_A-matched blood components Immunohematological differences between donor and recipient Dependent on the degree of blood group matching Accidental similarity dependent on ethnic backgrounds Alio- and autoantibodies in plasma Endogenous materials released after blood donation Cytokines (IL-1, IL-6, IL-8, TNFa, etc.) from WBC Proteolytic enzymes (elastase, cathepsins, etc.) from WBC Metabolic products from erythrocytes and platelets Soluble antigens from erythrocytes, platelets and WBC Cellular debris from erythrocytes, platelets and WBC Exogenous materials, processing steps Bacterial and viral contamination Storage conditions (time, temperature, agitation) Stabilizers, anticoagulants and preservatives (adenine, glucose, sodium citrate, sodium dihydrogen phosphate, citric acid, mannitol)

Leaching of plasticizer from the plastic containers Chemicals used for viral inactivation (methylene blue) Cellular damage by gamma or ultraviolet irradiation haplotype profiles and thus may vary between different populations.

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