Info

Table 1 Continued

Other name (s)

Main reactivity of mAbs

Short characteristic of the CD molecule

Molecular weight reduced (kDa)

CD44 Pgp-1; gp80-95; In (Unrelated p80, Hermes antigen, ECMR-III and HUTCH-I CD44R CD44 variant; CD44v9

CD45 T200; leukocyte common antigen (LCA); EC3.1.3.4

CD45R0 Restricted T200; gp180

T, B, G, M Receptor for hyaluronate and Involved in lymphocyte homing

T act, carcinoma cells Leukocytes

CD45RA Restricted T200; gp220;

isoform of leukocyte common antigen CD45RB Restricted T200; isoform of leukocyte common antigen CD45RC Restricted T200; isoform of leukocyte common antigen

CD46 Membrane cofactor protein (MCP); gp45-70

Leukocytes broad

CD47 Integrin associated protein;

OA3; 1D8 CD48 gp41; BLAST-1

CD49a VLA-1 a chain

CD49b VLA-2 a chain platelet glycoprotein GPIa

CD49c VLA-3 a chain

CD49d VLA-4 a chain

CD49e VLA-5 a chain

CD49f VLA-6 a chain

CD50 Intercellular adhesion molecule 3 (ICAM-3)

CD44R (CD44v9) may be a marker for cell transformation Transmembrane glycoprotein consisting of 4 isoforms, which result from differential splicing. The CD45 molecule has intrinsic cytoplasmic protein tyrosine phosphatase activity Isoform of the CD45 molecule family, this isoform does not contain exon A, B, or C sequences. Interacts via carbohydrate residues with the CD22 molecule Isoform determinant of CD45 sharing exon A sequences. Expressed on resting/naive T cells

Isoform determinant of CD45 sharing exon B sequences

Isoform determinant of CD45 sharing exon C sequences within CD4 cells expressed on long living memory cells Member of the RCA gene family (see CD21, CD35, CD55). Inhibits complement activation by inhibition of C3 convertase formation. Receptor for measles virus

Physically and functionally associated with the vitronectin receptor (CD51/CD61) Glycophosphatidylinositol-linked glycoprotein.

Counter-receptor for CD2 Associates with the CD29 molecule to form the VLA-1 (integrin a,/?,) complex. VLA-1 mediates cell adhesion to collagens and laminin Associates with CD29 molecules to form the VLA-2 (integrin a2j3,) complex. Functions as collagen receptor or collagen/lamlnin receptor, receptor for echovirus 1 Associates with CD29 molecule to form the VLA-3 {integrin a3ft) complex. VLA-3 mediates cell adhesion to fibrinogen, laminin, collagens and epiligrin/kalinin, VLA-2 M, T, B, (LHC), Thy Associates with CD29 molecules in VLA-4 (integrin a4/3,) which binds fibronectin, thrombospondin, invasin and CD106 molecules. Upon noncovalent association with the integrin li7 subunit the integrin a„/37 complex is formed, which binds fibronectin, MadCAM and CD106 molecules

T, M, Pit Associates with CD29 molecules to form the

VLA-5 (integrin a5j3,) complex, which is a receptor for fibronectin Pit (T) Associates with CD29 molecules in VLA-6

(integrin a6/3,). This complex has been shown to be a laminin receptor. The CD49f molecule can also associate with CD104 molecules to form the a6/34 laminin receptor Broad, not on EC Functions as counter-receptor for LFA-1 (CD11a/CD18)

Extremely broad Leukocytes T cultured

Pit, T cultured

Adherent cell lines

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