Info

Engulfmertt

Phagosome lormalton

AckHlieaton

Proteolysis

Lysosomal fusion Digestion

- Secretion

Ag processing interactions with dendritic colls, T lymphocytes

Phagosome Merit twane AlSf&tion

Mombrarco d Eruption/ Ins ion

Figure 4 Stages of uptake of a hypothetical pathogen by macrophages. Receptors involved in phagocytic recognition are shown, as are potential steps of evasion of host killing mechanisms. Some of the Mu responses are listed. FA-11 (macrosialin, the murine homolog of CD68) is a pan-Me glycoprotein abundantly expressed in phagosomes. Selected phagocytic stimuli alter the glycoforms of this membrane molecule profoundly, possibly contributing to phagosomal membrane resistance to intravacuolar enzymes and acidification.

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