Info

passage

Yes

No

Yes

ER to endosome targeting

Signal in the cytoplasmic tail

Not applicable

Signal in the li

p2m association

Yes

Yes

No

T cell recognition

CD4-/CD8 , CD8-, CD4+

Mostly CD8+

CD4'

Nature of antigens presented

Lipid, glycolipid and long

Mostly peptides, 8-10 amino

Mostly peptides, 8-20 amino

hydrophobic peptides

acids long

acids long

hydrophobic peptides. It is clear that further biochemical studies and the determination of the crystal structures of both mouse and human CD1 are needed to elucidate these issues.

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