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98-107 (106a)

CDR (complementarity-determining region), FR (framework region). The numbering system serves to optimally align conserved residues. Length variations are labeled with letters.

CDR (complementarity-determining region), FR (framework region). The numbering system serves to optimally align conserved residues. Length variations are labeled with letters.

generate a population of B cells producing antibodies with a diverse array of antigen-combining sites in order to interact specifically with the myriad of antigenic structures which can invade a host. There are several mechanisms used for generating this diversity in the variable domains of human immunoglobulins. They include 1) the innate diversity in the sequences of the V (variable), D (diversity) and J (joining) gene segments, 2) site-specific DNA rearrangement of the

V, D and J gene segments, 3) deletion of nucleotides at joining regions by nucleases, 4) insertion of non-templated and templated nucleotides at joining regions, 5) fusion and inversion of D regions, 6) pairing of light and heavy chains, and 7) somatic hvper-mutation. The result of these mechanisms is the production of an estimated 1014 different antibodies in humans.

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