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*See Loffert et al (1994) for more details. "Germline.

a RAG-1 is re-expressed in germinal center B cells, the functional significance unknown. *TdT is not expressed in fetal liver B cells, hence their Ig genes lack N-region additions.

*See Loffert et al (1994) for more details. "Germline.

a RAG-1 is re-expressed in germinal center B cells, the functional significance unknown. *TdT is not expressed in fetal liver B cells, hence their Ig genes lack N-region additions.

antigen receptors of defined specificity, have greatly deepened our understanding of the molecular and biologic processes involved in B cell differentiation. Because of the importance of these experiments they will be referred to when appropriate and the pheno-types of mice that have had molecules important in B cell differentiation altered by gene targeting have been summarized in Table 2. While there are some minor differences between human and mouse B cell differentiation, the overall scheme is remarkedly similar.

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