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Figure 1 Map of HSV infection and immune responses. (A) Acute Infection: 1, HSV productively infects cells of the epithelium; 2, viral progeny transfer to neural dendrites which they infect; 3, naked viral capsids are transported up the neuron axon to the cell body; 4, productive infection may occur or latency may be established In the nucleus. (B) Reactivation: 5, a latent infection is reactivated to produce progeny in the cell body; 6, progeny are transported down the nerve axon; 7, virions Infect epithelial cells to cause a productive lytic Infection; 8, virus may be transferred to an uninfected individual.

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