Footpad Response

Figure 2 Effects of transfer factors on genetically controlled immune responses. CBA and BALB/c mice were immunized with ovalbumin (OVA) in Freund's complete adjuvant. After 3 weeks some animals were tested for DTH with the footpad swelling assay; others were euthanized and the spleens were collected for isolation of the ova-specific transfer factor. The CBA mice did not develop DTH to ovalbumin and their spleen cell extracts did not contain OVA-transfer activity that would transfer DTH to CBA (low-responder) or BALB/c (high-responder) recipients. The CBA donors produced a transfer factor that was specific for tuberculin (PPD) indicating that failure to produce the OVA transfer factor was related to the low responder phenotype. BALB/c mice expressed DTH to OVA and their spleen cell extracts produced an OVA-specific transfer factor. Moreover, the same transfer factor could transfer the ability to express DTH to OVA to low-responder CBA recipients. (Reproduced with permission from Kirkpatrick CH (1988) Transfer factor. Journal of Allergy and Clinical Immunology 81: 803-813.)

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