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With permission of GG de Lange, personal communication.

findings may have implications for disease susceptibility. Such an effect has been reported for post-immunization levels of antibody to Haemophilus influenzae and Meningococcus C polysaccharides with individuals lacking the Kml and G2m(n) allotype having an increased risk of infection. A more established finding is an interactive effect between Gm allotypes and HLA antigens on disease susceptibility. There is some evidence that antibody molecules of the same isotype but differing allotype may differ in their potential to activate effector mech anisms.

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