Interleukin 13 And Its Receptor

Juha Punnonen, José M Carballido, Gregorio Aversa and Jan E de Vries,

Human Immunology Department, DNAX Research Institute of Molecular and Cellular Biology, Inc., Palo Alto, California, USA

Copyright © 1998 Elsevier Ltd. All Rights Reserved.

Interleukin 13 (IL-13) has biological activities on B cells, monocytes/macrophages and endothelial cells. IL-13 is primarily produced by TH2 cells, but it is also secreted by other T helper cell subsets CD8+ T cells, mast cells, eosinophils and basophils following activation. IL-13 induces proliferation and immunoglobulin E (IgE) synthesis by human B cells, suggesting that it may play a role in the pathogenesis of IgE-mediated allergic diseases. Moreover, IL-13 inhibits production of proinflammatory cytokines and chemokines by monocytes/macrophages both in vitro and in vivo, indicating that IL-13 also has important anti-inflammatory properties.

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