Stephen J McSorley, Institut de Pharmacologie Mol├ęculaire et Cellulaire, Valbonne, France Foo Y Liew, Department of Immunology, Western Infirmary, Glasgow, UK

Leishmaniasis is a parasitic human infection of global importance for which no reliable vaccine currently exists. Infection can result in the development of different disease states which constitute a spectrum of pathology from cutaneous lesion to fatal visceral infection. Mouse models of infection, which also display a similar spectrum of disease, have allowed a clear understanding of the mechanisms of susceptibility and resistance to this infection, making experimental leishmaniasis the best model system for the examination of T cell subset polarization and its relationship to pathogenesis.

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